Questran [Cholestyramine] users most commonly experience constipation which can be prevented by consuming lot of water and other non alcoholic beverages. Other common side effects of Questran [Cholestyramine] include gastritis, stomach upset, indigestion, heartburn, cramps in abdomen, vomiting, nausea, diarrhea and hemorrhoids irritation. In rare cases Questran [Cholestyramine] users may experience muscle aches, difficulty in swallowing, pain and stiffness in joints, headache, anal irritation and unusual bleeding or bruising. Contact the doctor immediately if the problem is seen or persists. Questran [Cholestyramine] could also experience tooth decay and tooth decoloration if the liquid stay in mouth for longer time duration.