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  Mens Health» CIALIS [TADALAFIL] tah-DA-la-fil

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Description
Cialis [Tadalafil] is an almond shaped oral pill used for erectile dysfunction treatment. The active ingredient present in Cialis is Tadalafil. In each tablets 2.5 5 10 or 20mg of tadalafil and other inactive ingredients are constituted. Tadalafil present in Cialis is a Phosphodiesterase type 5 PDE5 Inhibitor. Sex stimulation releases Nitric Oxide NO which stimulates the synthesis of cyclic guanosine monophosphate cGMP in smooth muscle in penis and relaxes it and increases blood flow to the corpus cavernosum of penis causing penile erection. Cialis’s pharmacologic distinction is its longer half-life 17.50 hours or 36 hours effectiveness compared to other PDE5 inhibitors like Viagra and Levitra which are 4-5 hours resulting in longer duration of action. That is why it has earned a nickname’ The Weekend Pill ’. Cialis has recently been approved for the treatment of Pulmonary Arterial Hypertension PAH minimizing the risk of right heart failure and respiratory failure. Cialis is considered as one of the best erectile dysfunction drugs.

Erection of the penis is caused by the filling of the penis with blood. Filling occurs because the blood vessels that bring blood to the penis increase in size and deliver more blood to the penis and at the same time the blood vessels that take blood away from the penis decrease in size and remove less blood from the penis.

Sexual stimulation that leads to an erection causes the production and release of nitric oxide in the penis. The nitric oxide causes an enzyme guanylate cyclase to produce cyclic guanosine monophosphate cGMP. It is the cGMP that is primarily responsible for increasing and decreasing the size of the blood vessels carrying blood to and from the penis respectively and causing the erection. When the cGMP is destroyed by another enzyme phosphodiesterase-5 the blood vessels return to their normal size blood leaves the penis and the erection ends. Tadalafil prevents phosphodiesterase-5 from destroying cGMP so that cGMP stays around longer. The persistence of cGMP leads to a more prolonged engorgement of the penis with blood.

Tadalafil was approved by the FDA in November 2003.

How to use
The recommendation of initial dose of Cialis [Tadalafil] for use as needed for most patients is 10mg approximately 30 minutes prior to sexual activity but not more than once daily. The dose may be increased to 20 mg or decreased to 5mg as per efficacy and mans personal tolerance of the drug. It is recommended that low dose of Cialis 2.5mg and 5mg to be used daily as erectile dysfunction therapy. Cialis at a dose of 40 mg once daily has been approved for treating pulmonary arterial hypertension. Patients undergoing medications that increase the blood levels of tadalafil should not exceed a total Cialis dose of 10 mg in 72 hours. Cialis can be taken with or without food.
Side Effects
The most common side effects experienced while using Cialis [Tadalafil] are headache indigestion muscle aches back pain flushing and stuffy or runny nose. These side effects reflect the ability of PDE5 inhibition to cause blood vessels to widen which usually goes away after few hours. Muscle aches and back pain are usually experienced after 12 to 24 hours after taking Cialis which disappears after 2 days. Vision impairment is also experienced by those who take Cialis. Sudden hearing loss is a potential risk for Cialis users. Apart from these other side effects experienced by individuals taking Cialis are blurred vision low blood pressure change in color vision and abnormal ejaculation. Tadalafil present in Cialis has been associated with prolonged and painful erection lasting more than 6 hours.
Drug Interaction
Cialis [Tadalafil] as PDE5 inhibitor may cause low pressure or hypotension. Organic nitrates should not be consumed before 48 hours of last dose of Cialis or it may increase the risk of life-threatening hypotension.
Co-administration of antacid and Cialis reduce the apparent rate of absorption of tadalafil without altering exposure to tadalafil.
Drugs like erythromycin indinavir ketoconazole and ritonavir reduces the breakdown and elimination of tadalafil from the body. Therefore these drugs increase the level of tadalafil in the blood. Dose of Cialis should be reduced in order to avoid side effects from high levels of tadalafil when the said drugs are co-administered with Cialis.
Cialis [Tadalafil] taken with alcohol may result in low blood pressure palpitation dizziness and headache.
Uses
Cialis [Tadalafil] is mainly used for the treatment of male impotency and erectile dysfunction. Cialis is also approved for the treatment of pulmonary arterial hypertension.
Storage
Cialis [Tadalafil] can be stored for a brief period of time at a temperature between 15 o to 30 o C 59 o - 86 o F. Preferably Cialis should be stored at a temperature of 25 o C 77 o F. It should be kept away from light heat and moisture.
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