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  Anti-Depressant» TRAZODONE-(traz oh done)
Desyrel (Generic)
Brand : Desyrel (Generic)
Composition : TRAZODONE-(traz oh done)
Desyrel 25mg
Qty.TypeOur PriceOther PriceBuy
30Tab$5.99 US$50 US   Buy Desyrel
90Tab$15.99 US$145 US   Buy Desyrel
Desyrel 50mg
Qty.TypeOur PriceOther PriceBuy
30Tab$10.99 US$60 US   Buy Desyrel
90Tab$30.99 US$166 US   Buy Desyrel
Desyrel 100mg
Qty.TypeOur PriceOther PriceBuy
30Tab$15.99 US$99 US   Buy Desyrel
90Tab$46.99 US$290 US   Buy Desyrel
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Description
Trazodone is an oral antidepressant drug that affects the chemical messengers (neurotransmitters) within the brain that nerves use to communicate with (stimulate) each other. The major neurotransmitters are acetylcholine, norepinephrine, dopamine and serotonin. Many experts believe that an imbalance among the different neurotransmitters is the cause of depression. Although the exact mechanism of action of trazodone is unknown, it probably improves symptoms of depression by inhibiting the uptake of serotonin by nerves in the brain. This results in more serotonin to stimulate other nerves. Trazodone also may increase directly the action of serotonin. Trazodone is chemically unrelated to the serotonin reuptake inhibitors (SSRIs), the tricyclic antidepressants (TCAs) or the monoamine oxidase inhibitors (MAO inhibitors). It is chemically related to nefazodone (Serzone) and shares its actions. Trazodone was approved by the Food and Drug Administration in 1982.
How to use
For the treatment of depression, the dose for adults is 150-600 mg per day. The initial starting dose usually is 150 mg per day. Trazodone is given in one or more daily doses, sometimes with the largest dose at night. As with all antidepressants, it may take several weeks for the full effects of treatment to be seen. Doses often are adjusted slowly upwards to find the optimal dose. Elderly patients and debilitated persons may need lower doses. Trazodone should be taken after a meal or light snack to reduce the risk of dizziness. Food also increases the amount of drug absorbed into the body.
Side Effects
All antidepressants that increase concentrations of serotonin in the brain, including trazodone, should not be taken with MAO-inhibitors. Drugs in the MAO-inhibitor class include isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane). Such combinations may lead to confusion, high blood pressure and tremor. This same type of interaction may occur when trazodone is used with selegiline (Eldepryl). If a patient is switched from trazodone to an MAO inhibitor, at least one week should be allowed after stopping the trazodone before the MAO inhibitor is begun.

Increased blood concentrations of digoxin and phenytoin have been reported in persons taking trazodone due to a decrease in the metabolism (break-down and elimination) of these drugs by trazodone
Drug Interaction
All antidepressants that increase concentrations of serotonin in the brain, including trazodone, should not be taken with MAO-inhibitors. Drugs in the MAO-inhibitor class include isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane). Such combinations may lead to confusion, high blood pressure and tremor. This same type of interaction may occur when trazodone is used with selegiline (Eldepryl). If a patient is switched from trazodone to an MAO inhibitor, at least one week should be allowed after stopping the trazodone before the MAO inhibitor is begun.

Increased blood concentrations of digoxin and phenytoin have been reported in persons taking trazodone due to a decrease in the metabolism (break-down and elimination) of these drugs by trazodone
Uses
Trazodone is primarily used for the treatment of depression; however, it is sometimes prescribed as a sedative, and it also is used in combination with other drugs for the treatment of psychiatric conditions other than depression and cocaine withdrawal.
Other Uses
Trazodone also is used occasionally to treat anxiety and cocaine withdrawal. Talk to your doctor about the possible risks of using this drug for your condition.
Storage
Store at room temperature, 15-30?C (59-86?F)
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