Lamivudine-Stavudine [Lamivudine & Stavudine] is a type of antiretroviral drug which belongs to the class of nucleoside analogue. These drugs are used in the management of Human Immunodeficiency Virus infection Type 1 which is given in combination with other anti retroviral drugs. This combination can not only help in decreasing the pill burden but can also prove to accelerate the compliance in people who are infected with Human Immunodeficiency Virus. These drugs work as Anti-HIV Agents.
Lamivudine-Stavudine [Lamivudine & Stavudine] acts by inhibiting the reverse transcriptase enzyme of Human Immunodeficiency Virus and by stopping the growth of the DNA chain. They terminate the synthesis of DNA. The viral DNA growth is stopped as the formation of 5' to 3' phosphodiester linkage that is essential for the elongation of DNA chain is prevented. Stavudine when used in combination with lamivudine has synergistic antiretroviral activity.
The preparations of Lamivudine- Stavudine [Lamivudine & Stavudine] are available in the form of tablets. They are available as combination tablets. The composition of these tablets is available in two forms – (i) content of Lamivudine is 150mg and Stavudine is 40mg and (ii) content of Lamivudine is 150mg and Stavudine is 30mg.
Lamivudine- Stavudine [Lamivudine & Stavudine] is not to be given in patients who are sensitive to any of the components of this combination. Doubling of the dose and overdosing of the dose of Lamivudine-Stavudine [Lamivudine & Stavudine] is to be avoided in order to compensate fro the missed dose. Overdosing of Stavudine can lead to peripheral neuropathy and hepatic toxicity. Avoid stopping this medicine even for a short period of time. If the medicine is stopped or skipped without the consultation of your doctor then, it can boost the amount of virus and the infection can get still difficult to treat or it may even worsen the side effects.
How to use
Generally the recommended dose of Lamivudine- Stavudine [Lamivudine & Stavudine] is once or twice a day, as directed by the physician. It should be taken orally with or without food. The exact dosage of Lamivudine- Stavudine [Lamivudine & Stavudine] differs from person to person and hence it should be taken as directed by your physician.
Side Effects
Lactic Acidosis, Peripheral neuropathy, Pancreatitis, Severe Hepatomegaly with steatosis, headache, diarrhea, etc are few of the side effects that are experienced by Lamivudine- Stavudine [Lamivudine & Stavudine].
Drug Interaction
Ribavirin, Doxorubicin and Zidovudine are some of the drugs that interfere with the action of Lamivudine-Stavudine [Lamivudine & Stavudine].
Uses
Lamivudine- Stavudine [Lamivudine & Stavudine] is indicated in the management of Human Immunodeficiency Virus infection. Lamivudine-Stavudine [Lamivudine & Stavudine] is helpful in controlling the Human Immunodeficiency Virus infection by enhancing the quality of life of the patient and by decreasing the risk of complications.
Storage
Lamivudine-Stavudine [Lamivudine & Stavudine] should be stored in a cool and dry place, away from heat, moisture and light.
Precaution
• Keep your physician informed in case you are suffering from kidney disease, pancreatic disorders, hepatitis B, allergies, heart disease, alcohol usage, etc.
• This medication is to be used with great caution during pregnancy and is to be avoided during breast feeding.
• Avoid using this medication in pediatric cases.
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