Pyrazinamide is a bactericidal or bacteriostatic drug which is found effective in treating mycobacterium tuberculosis. Pyrazinamide helps in curing TB by inhibiting the growth of bacteria. Pyrazinamide is quickly absorbed after oral consumption and crosses the inflamed meninges which prove effective in treating tuberculosis meningitis.
Pyrazinamide is considered to be safe drug which can be used even during pregnancy. World Health Organization recommends the use of this drug for treating TB in pregnant patients. However this drug is not prescribed to pregnant ladies in US due to insufficient research that has been conducted regarding its use. As pyrazinamide can get removed from the body due to dialysis hence kidney patient should always take this drug after completing their dialysis.
Pyrazinamide in combination with other antituberculous agents like isoniazid and rifampin is prescribed for initial treatment of TB in both adults as well as children. This medicine for tuberculosis has to be taken for an initial 2 months and may have to be continued for another 4 months after consulting the doctor. Pyrazinamide is found effective in treating TB when other drugs have been unable to produce desired results. Patients suffering from HIV or other serious diseases may require taking this medication for longer period of time to get complete cure.
Pyrazinamide tablets available in market for oral consumption contain 500mg pyrazinamide along with inactive ingredients such as croscarmellose sodium, colloidal silicon dioxide, dibasic calcium phosphate, stearic acid and microcrystalline cellulose. For better results recommended doses of pyrazinamide has to be taken daily at the same time. No doses should be missed and no two doses should be taken at the same time to avoid any side effects.
This medication to treat tuberculosis is approved by FDA.
How to use
Pyrazinamide is available as tablets for oral consumption. This medicine for treating tubeculosis can be taken with or without food. For the initial couple of months a single dose may be prescribed daily or this medicine can be taken twice a week as per doctor’s recommendation. The dosage depends upon the person’s age, weight, medical history and also their response to the treatment. Pyrazinamide may be taken for 6-9 months for person to get completely cured. Only the prescribed dose of the medicine should be taken as missed dose as well as overdose can cause severe side effects.
Side Effects
Pyrazinamide users can commonly observe severe headache, joint pains, stomach upset or nausea during initial days. The problems usually subside after few days but the doctor should be consulted immediately if the problem persists. Pyrazinamide is considered to be a safe drug. However consult your physician immediately if you notice these rare side effects like fast or irregular breathing, pale skin, extreme fatigue and weakness, regular vomiting, yellowing of skin and eyes, blood in urine and swollen joints.
Drug Interaction
Pyrazinamide users should inform their doctor in advance about any other herbal or over the counter product that they are taking. Pyrazinamide can interact negatively with rifampin. Also this medication for tuberculosis can decrease the effectiveness of Zyloprim or allopurinol. Users taking pyrazinamide may not get correct results in Ketone tests.
Over Dose
If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.
Notes
Laboratory tests will be done periodically while taking this medication to monitor its effectiveness and to prevent side effects.
Missed Dose
If you miss a dose, take it as soon as remembered; do not take it if it is near the time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.
Uses
Pyrazinamide is essentially an antibiotic that is used in the treatment of active tuberculosis. It is always used in combination with other medications like rifampicin and isoniazid. Pyrazinamide is used with rifampin for curing latent tuberculosis. Pyranzinamide is also an effective antiuricosuric which is used for diagnosis of hyperuricosuria and hyperuricemia.
Storage
Pyrazinamide is stored at room temperature (15-30 degree Celsius) away from heat, light and moisture. The medicine should never be stored in bathroom and away from the reach of pet and children.
Precaution
Pyrazinamide users should inform their doctors about previous medical history and medicines that they are taking before starting with this medicine. Following precautions have to be taken by Pyrazinamide users:
• If they are allergic to any ingredient of pyrazinamide
• Suffer from liver and kidney disorder
• Have gout or diabetes mellitus
• Should be taken by pregnant ladies only if required and after consulting their doctors
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