Paliperidone is an anti-psychotic drug that is used especially in treating mental disorder schizophrenia. Paliperidone is usually available by the brand name Invega and works by harmonizing the flow of neurotransmitters in the patient’s brain. Paliperidone is not advised to be used for treating dementia related problems especially in elders as it can cause fatal side effects. Paliperidone is one of the metabolites of risperidone and helps in the treatment of schizophrenia dues to the presence of dopamine and serotonin Type 2 receptor antagonism.
Paliperidone should only be taken as per the doctor’s prescription. When the patient misses a dose of this medicine they should take the next dose at the schedule times. Two doses of this medicine should not be taken together as it can cause fatal side effects. Physicians should also be very cautious before prescribing Paliperidone to the patients and should inform them about potential side effects of this medication when starting with the treatment.
Patients using Paliperidone can suffer from orthostatic hypotension when the treatment or schizophrenia is started, reinitiated or doses are modified during the course of treatment. Use of Paliperidone can have an impact on patients thinking, judgment and motor skills and therefore patients after taking this medicine should not indulge in any high alertness activity after taking this medicine. Also Paliperidone can have an impact on the health of the unborn child and therefore if you are pregnant or plan to get pregnant during the course of treatment inform your doctor in advance. Paliperidone is also transferred to best milk and has to be avoided by feeding mothers. Doctor should also be informed of any prescription or over the counter drug that you are taking before starting with Paliperidone.
Paliperidone should always be taken with a full glass of water and should be swallowed. People should avoid hot humid climate while taking this medication. They should also take adequate fluid to avoid dehydration when taking Paliperidone.
How to use
Paliperidone doses are prescribed based on the severity of problem and patients reaction to the drug. Inform doctor about other medications that you are taking before starting with Paliperidone. The medicine can be eaten with food or even on empty stomach. Swallow Paliperidone with liquid and do not crush or chew the pill as it decreases the efficiency of the medicine and can even cause side effects. The maximum recommended dose of Paliperidone is 12 milligram and is usually taken once a day in the morning. Use this medicine same time everyday and don’t stop using this drug abruptly.
Side Effects
Common side effect seen by Paliperidone users includes abdominal pain, dizziness and drowsiness, cough and cold, sudden weight gain. These symptoms are only noticed during initial weeks of taking the medicine and then disappear slowly. In rare cases patient may experience difficulty in swallowing, tremors, muscle spasm, tremors, swelling and redness in body parts, slurred speech, blurred vision, problem in breathing, seizures etc. In extreme rare cases Paliperidone users may experience tardive dyskinesia which causes uncontrolled movement of body parts. In case of any of the above problems doctors should be consulted immediately.
Drug Interaction
Tell doctors about any other medication you are taking before using Paliperidone. Paliperidone could have negative interaction when it is taken with :
• Medications that have an effect on heart rhythm like amiodarone, quinidine etc
• Should not be used with sibutramine and herbal products like anticholinergics such as belladonna, alkaloids etc
• Should not be taken with alpha blockers, Parkinson disease medicine, diuretics and ACE inhibitors.
• Paliperidone should be avoided if you are taking medicines for sleep, anxiety, and narcotic pain reliever, muscle relaxant, anti seizure and antihistamine medicines.
Notes
bPaliperidone is not approved by the FDA for the treatment of behaviour problems in older adults suffering from dementia.
Paliperidone is an antipsychotic which increases the risk of death when used to treat mental problems caused by dementia in elderly patients. Paliperidone is not approved to treat mental problems caused by dementia.
Studies show older adults with dementia who take antipsychotic medication such as paliperidone for mental illness face an increased risk of death during treatment may also have a greater chance of a stroke or a small stroke during the course of treatment with this medicine. Most deaths were linked to heart problems or infection.
If you experience:
slow or difficult speech
dizziness
feeling faint
weakness/numbness of an arm or leg call your health care professional immediately.
Speak with your health care professional who has prescribed this medication for the treatment if you or a family member or someone you care for has dementia and is undergoing treatment for the same with paliperidone./b
Uses
Paliperidone is an anti psychotic drug which is usually prescribed for the treatment of mental disorders like schizophrenia. It works by neutralizing the natural chemicals called neurotransmitters in patient’s brain. Paliperidone can be used to control hallucination and makes the person feel less agitated and feel positive.
Storage
Paliperidone should be stored at 77 degree F. For small duration Paliperidone can be kept between 59-86 degree F. The medicine should be stored away from light and moisture. This medicine should be kept away from pets and children.
Precaution
Following precautions should be kept in mind by the Paliperidone users:
• Tell your physician in advance if you are allergic to risperidone or any such medicine
• Patient having heart rhythm disease like QTc prolongation, diabetes, liver and kidney disease, potassium and magnesium imbalance, blockage disorders, blood pressure problem, diabetes, heart disease, problems in blood vessels should always consult their doctors before taking Paliperidone
• Paliperidone can cause drowsiness hence one should not indulge in high alertness requiring activity after taking this medicine
• One should abstain from alcohol and drugs when taking Paliperidone.
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