Zidovudine is an oral and injectable medication that is used for the treatment of infections with the human immunodeficiency virus (HIV). It is in a class of drugs called reverse transcriptase inhibitors which also includes zalcitabine (Hivid), stavudine (Zerit), didanosine (Videx), and lamivudine (Epivir). During infection with HIV, the HIV virus multiplies within the body's cells. The newly-formed viruses then are released from the cells and spread throughout the body where they infect other cells. In this manner, the infection continually spreads to new, uninfected cells that the body is continually producing, and HIV infection is perpetuated. When producing new viruses, the HIV virus must manufacture new DNA for each virus. Reverse transcriptase is the enzyme that the virus uses to make this new DNA. Zidovudine inhibits the activity of reverse transcriptase and blocks the production of DNA and new viruses. Specifically, zidovudine is converted within the body to its active form (zidovudine triphosphate). This active form is similar to the compound thymidine triphosphate, a chemical that is required by the HIV virus to make new DNA. The reverse transcriptase uses zidovudine triphosphate instead of thymidine triphosphate for making DNA, and it is the zidovudine triphosphate that interferes with the reverse transcriptase. Zidovudine does not kill existing HIV virus, and it is not a cure for HIV. Retrovir was approved by the FDA in 1987.
How to use
Retrovir [Zidovudine] is usually taken along with other HIV medicines. It should be consumed on empty stomach but in case there are instances of irritation in the stomach then it can be taken along with food. 200 mg of Retrovir [Zidovudine] is to be taken three times daily or 300 mg is to be taken twice daily.
Side Effects
Few of the side effects experienced when taking Retrovir [Zidovudine]are as follows:- insomnia, pain in head, muscle pain, nausea, weakness, loss of appetite, vomiting, abdominal pain, joint pain, indigestion, pain in bones, nerve problems, anemia, confusion, bone marrow damage, etc.
Drug Interaction
Some of the drugs that interfere with the action of Retrovir [Zidovudine] are - Atovaquone; Doxorubicin; Ganciclovir; interferon medications; fluconazole; methadone; probenecid; nelfinavir; rifapentine; ritonavir; rifampin; ribavirin; stavudine; Valganciclovir; etc.
Uses
Retrovir [Zidovudine] is used for the treatment of HIV infection and AIDS. It prevents the transmission of HIV from an infected mother to her fetus.
Storage
Store Retrovir [Zidovudine] at room temperature between 59 and 86 degrees F (15 and 30 degrees C) and keep it far from heat, moisture and sunlight.
Precaution
• Keep your doctor informed if you suffer from anemia, blood disorders or bleeding disorders, kidney disease, liver disease, heart troubles, allergies or addictions.
• Avoid breast feeding when taking this drug.
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