Rifadin is composed of an active ingredient Rifampin and other inactive ingredients. Rifampin belongs to a class of medicine known as Rifamycin antibiotic. Rifadin [Rifampin] is available in a form of capsules, syrup and intravenous infusion. Capsules are available in two strengths, 150 mg and 300mg. Rifadin [Rifampin] is most frequently used for the treatment of tuberculosis (TB). It is also used for the treatment of infections caused by certain other bacteria. Rifadin [Rifampin] works by killing the bacteria that cause the infection. There is a bacterial enzyme known as RNA-polymerase. These bacteria use RNA-polymerase to make essential proteins and copy their own genetic information i.e. DNA and thereby multiplies in numbers. Without this RNA-polymerase bacterial enzyme they cannot reproduce and will die. Rifadin [Rifampin] is used along with other anti-tuberculosis drugs to resist the growth of bacteria, to kill the resistance power of the bacteria and make the drugs more effective for the purpose.
How to use
The recommended dosage that Rifadin [Rifampin] should be administered in empty stomach, once daily, 1 hour before or 2 hours after meal with a full glass of water.
If the patient is suffering from nausea, the antacid should not be taken with this drug or else it will reduce the effectiveness of the drug. If the patient had to take antacid, then, it should be administered at least 1 hour after the administration of Rifadin [Rifampin].
If the medication is syrup, then shake the bottle well before use.
In case of tuberculosis treatment, Rifadin [Rifampin] is used for both stages. Firstly for first 2 months when the treatment is aimed at killing as many bacteria as possible with several anti-TB drugs with different mechanisms of action are used at the same time. Secondly for next 4 months when few medicines are stopped and it is used to kill the remaining bacteria.
Side Effects
Side effects indicated using Rifadin [Rifampin] medication are; reddish coloration of urine, saliva and tears, nausea, vomiting, diarrhea, abdominal discomfort, loss of appetite, headache, drowsiness, allergic skin rashes, flushing, itching, jaundice, hepatitis, colitis, thrombocytopenia, muscle weakness, edema, flu-like symptoms, menstrual disturbances, decrease in blood pressure, shortness of breath, kidney failure and haemolytic anaemia.
Drug Interaction
Concomitant use of Rifadin [Rifampin] and ritonavir or saquinavir, which are used for HIV infections, may increase the risk of side effects on liver.
Concomitant use of Rifadin [Rifampin] and antacids, which are used to treat indigestion and heartburn, may reduce the absorption of rifampim from the gut.
Concomitant use of Rifadin [Rifampin] and medicines like anticoagulants, anti-diabetics, azole anti-fungals, beta blockers, calcium channel blockers, clarithromycin, corticosteroids, digoxin, may decrease the effect of these medicines as rifampin increases the activity of enzymes in the liver and breaks down all these medicines and increases the removal of these medicines from the body.
Over Dose
If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly. Symptoms of overdose may include swelling of face or around eyes, itching over the entire body, orange or red discoloration of skin or eyes, nausea, vomiting, drowsiness, and loss of consciousness.
Notes
Laboratory tests will be done periodically while taking this medication to monitor its effects. Do not share this medication with others.
Missed Dose
If you miss a dose, take as soon as remembered; do not take if it is almost time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
Uses
Rifadin [Rifampin] is used for the treatment of tuberculosis in combination with other anti-tuberculosis medicines. It is also used for the treatment of leprosy in combination with at least one other anti-leprosy medicine. It is used for the treatment of infections caused by brucella bacteria, staphylococcal bacteria and Legionnaires’ disease in combination with other antibiotics. It is also used for the prevention of meningococcal meningitis and infections and disease caused by haemophilus influenza bacteria.
Storage
Rifadin [Rifampin] should be stored in a temperature between 15o-30oC (59o-86oF). Avoid excessive heat, light and moisture.
Precaution
Rifadin [Rifampin] should be used cautiously among the patients those who are elderly, those who have decreased liver or kidney function, those who are alcoholic and those who have hereditary blood disorder called porphyrias.
Rifadin [Rifampin] medication is not recommended to those who are suffering from jaundice and those who are allergic to rifamycin antibiotics.
Pregnant women and nursing mothers should seek consultancy with the physician before administering the medicine.
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