Starlix [Nateglinide] is an oral medication used in the management of Type 2 diabetes mellitus. It is administered in combination with exercise and diet to derive maximum benefits.
How to use
Starlix [Nateglinide] should be administered as per the doctor’s instructions. This medication is to be administered alone or in combination with thiazolidinedione or metformin. In both the situations, the starting and maintenance dosage is 120 mg thrice a day.
Patients who are near goal HbA1C are prescribed the 60 mg-dose of Starlix [Nateglinide] either by itself or in combination with thiazolidinedione or metformin.
Geriatric patients should be thoroughly examined by the doctor before the dosage is decided.
Starlix [Nateglinide] should be prescribed by the doctor with caution to patients suffering from moderate to severe liver disease.
Side Effects
Starlix [Nateglinide] may cause side effects in some patients. Hypoglycemia is a rare side effect of the medication while nausea and diarrhea are more common. Other side effects are peripheral edema, urticaria, rash, jaundice, elevated liver enzymes, cholestatic hepatitis and itching.
Drug Interaction
Starlix [Nateglinide] may cause certain drug interactions when taken in combination with other medications. The doctor should be informed of all the medications a patient is being administered including over the counter, prescription, herbal, vitamins and mineral supplements before he prescribes Starlix [Nateglinide]. This medication should never be taken with gatifloxacin as it may cause extremely serious drug interactions.
Caution should be exercised in taking this medication in combination with over the counter drugs like tolbutamide, phenytoin and warfarin.
There are some drugs which may cause fluctuation in the blood sugar levels or may make the management of diabetes more difficult when taken in combination with Starlix [Nateglinide]. For e.g., oral corticosteroids (dexamethasone, prednisolone, prednisone), drugs taken for mood disorders (clozapine, risperidone, olanzapine, ziprasidone), estrogens, niacin, isoniazid, calcium channel blockers (nifedipine), fenugreek, ginseng, alcohol, protease inhibitors (amprenavir, amprenavir), diuretics (hydrochlorothiazide, furosemide), phenothiazines (trifluoperazine, chlorpromazine), birth control pills, sympathomimetics (pseudoephedrine), estrogens, thyroid drugs, beta blockers (propranolol), gymnema and protease inhibitors (amprenavir, indinavir).
Uses
Starlix [Nateglinide] is used in the treatment and management of glucose control in patients with Type 2 diabetes mellitus. It is recommended to be administered along with diet and exercise to derive the maximum benefit.
Storage
Starlix [Nateglinide] should be kept stored in a cool and dry area. It should be kept away from excess moisture, direct sunlight and excessive heat. It should be kept out of reach of children and pets.
Precaution
Before starting therapy using Starlix [Nateglinide], the doctor should be aware of any allergies the patient may have. Also, the doctor should be aware if the patient has Type 1 Diabetes mellitus or a condition where blood sugar is uncontrollable known as ketoacidosis.
Consumption of alcohol should be stopped or reduced while therapy is on.
Fever, injury, quitting to smoke, infection and surgery may require a change in dose.
Pregnant women and breastfeeding mothers should let the doctor know of their condition before starting therapy.
This medication should not be prescribed on patients with low blood sugar levels.
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