Nevirapine as an active ingredient and with other inactive ingredients constitute the medicine Viramune in a form of tablet with the strength of 200mg of Nevirapine; and oral suspension with the strength of 50mg of Nevirapine in every 5ml of Viramune. Viramune [Nevirapine] medicine is used as a treatment for HIV and AIDS. It should be used in combination with other medications of HIV. It is not approved to be used by itself. Viramune [Nevirapine] belongs to a type of medicine known as Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs). HIV (Human Immunodeficiency Virus) is a virus that causes AIDS (Acquired Immune Deficiency Syndrome). Like other viruses, HIV uses a person’s own cells to reproduce. But there is a difference. First it converts its genetic material from RNA to DNA by a special protein known as Reverse Transcriptase Enzyme. To create DNA, this enzyme uses several different protein building blocks. Then these DNA genes allow HIV to multiply. Viramune [Nevirapine] works by attaching itself to Reverse Transcriptase Enzyme, stopping it from making DNA. HIV cannot multiply without DNA. Viramune [Nevirapine] is not a cure for HIV or AIDS. It helps by stopping HIV infecting uninfected cells in the body. But it cannot help or cure the cells that are already being infected by the virus.
How to use
The recommended initial dosage of Viramune [Nevirapine] for treating adults with HIV or AIDS is 200mg, once a day for first 14 days. Then it should be followed by 200mg of Viramune [Nevirapine], twice daily.
The recommended initial dosage of Viramune [Nevirapine] for treating pediatrics from 15 days and above is 150mg/m2, once a day for first 14 days. Then it should be followed by 150mg/m2 of Viramune [Nevirapine], twice daily.
The total daily dosage should not exceed 400mg for any patient.
It can be taken with or without food.
Side Effects
The most common side effects indicated using Viramune [Nevirapine] medication are nausea, fatigue, headache, diarrhea, abdominal pain and muscle pain.
Other side effects that are indicated are signs of liver damage such as malaise, loss of appetite, nausea, jaundice, tenderness near liver and pale stool; changes of distribution of fat in the body; and any rash that are accompanied by certain symptoms like general ill feeling, fatigue, joint pain, skin blisters, mouth sores, eye redness, swelling of face and liver problems.
Drug Interaction
There are few medications when used concurrently with Viramune [Nevirapine] result in decrease in the level of those medications in blood and makes them less effective. Those medications are arrhythmia medication, calcium channel blocker, certain antibiotics or antifungals, chemotherapy medication, efavirenz, ergot medication, fentanyl, immune suppressing medication, methadone and protease inhibitors.
Concomitant use of Viramune [Nevirapine] and oral contraceptives result in; decrease the effectiveness of contraceptives and increase the risk of pregnancy.
Concomitant use of Viramune [Nevirapine] and St. John’s wort result in; decrease in the level of nevirapine in blood, making it less effective.
Uses
Viramune [Nevirapine] is used for treating HIV and AIDS in adults and children by attaching to special protein known as Reverse Transcriptase Enzyme in the body and stopping DNA from being multiplied. It’s not a cure to HIV or AIDS but helps in stopping the uninfected virus getting infected.
Other Uses
This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
Storage
Viramune [Nevirapine] should be stored at a temperature of 25°C (77°F), excursions permitted to 15°-30°C (59°-86°F).
Precaution
Viramune [Nevirapine] can cause life-threatening skin rashes and severe liver damage. So, closely monitoring by the physician is necessary for first 18 weeks after starting the dose.
Patients with cirrhosis of liver or hepatitis or any allergies should consult the physician before administering the medication.
Pregnant women and lactating mothers should be cautious and consult the physician prior to administering the medication.
Practice safer sex even if undergoing the medication.
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